Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.

Cellular and molecular life sciences : CMLS - 1 Jul 2013

Cao Yu, Zhang Lingqiang

Abstract excerpt

Since being discovered and intensively studied for over a decade, Smad ubiquitylation regulatory factor-1 (Smurf1) has been linked with several important biological pathways, including the bone morphogenetic protein pathway, the non-canonical Wnt pathway, and the mitogen-activated protein kinase pathway. Multiple functions of this ubiquitin ligase have been discovered in cell growth and morphogenesis, cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Diseases
Share to Cell Physiological Phenomena
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Osteogenesis

Share to Proteolysis

Share to Ubiquitin-Protein Ligases

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 23007848
DOI: 10.1007/s00018-012-1170-7
PMCID: PMC11113965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.PMID 23007848Read ↗

Smurfs in Protein Homeostasis, Signaling, and CancerSemantic proximity Read ↗

The Post-translational Modifications of Smurf2 in TGF-β SignalingSemantic proximity Read ↗

Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling.Semantic proximity Read ↗

The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial–mesenchymal transition in a sumoylation-regulated mannerSemantic proximity Read ↗

Smad Ubiquitination Regulatory Factor 2 Promotes Metastasis of Breast Cancer Cells by Enhancing Migration and InvasivenessSemantic proximity Read ↗

E3 ubiquitin ligases: key regulators of osteogenesis and potential therapeutic targets for bone disordersSemantic proximity Read ↗

Ubiquitination of Smad2 by Smurf1 inhibits endothelial-to-mesenchymal transition in human coronary artery endothelial cellsSemantic proximity Read ↗

The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.Semantic proximity Read ↗

Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligaseSemantic proximity Read ↗

RNF4—A Paradigm for SUMOylation‐Mediated UbiquitinationSemantic proximity Read ↗

Smurf E3 ubiquitin ligases at the cross roads of oncogenesis and tumor suppressionSemantic proximity Read ↗

Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.