Article

A requirement for Krüppel-Like Factor-4 in the maintenance of endothelial cell quiescence

2022-05-10

Abstract excerpt

<h4>Rationale and Goal</h4> Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor angiogenesis. Here, we addressed the hypothesis that KLF4 maintains the EC quiescence. <h4>Methods and Results</h4> In ECs, KLF4 bound to KLF2, and the KLF4-tran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8253f095-b054-5125-b21b-66c092864f0d
DOI: 10.1101/2022.05.09.491221

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A requirement for Krüppel-Like Factor-4 in the maintenance of endothelial cell quiescenceDOI 10.1101/2022.05.09.491221Read

Krüppel-like factors in endothelial cell biologySemantic proximity Read

Endothelial to mesenchymal transition: at the axis of cardiovascular health and diseaseSemantic proximity Read

Endothelial cell flow-mediated quiescence is temporally regulated and utilizes the cell cycle inhibitor p27Semantic proximity Read

The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endotheliumSemantic proximity Read

Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury.Semantic proximity Read

DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.Semantic proximity Read

Role of Krüppel-Like Factor 4 and its Binding Proteins in Vascular DiseaseSemantic proximity Read

Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitmentSemantic proximity Read

Ubiquitination of Smad2 by Smurf1 inhibits endothelial-to-mesenchymal transition in human coronary artery endothelial cellsSemantic proximity Read

Fine‐tuning vascular fate during endothelial–mesenchymal transitionSemantic proximity Read

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell TranscriptomeSemantic proximity Read

E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial HypertensionSemantic proximity Read