Article

GLUCURONIDATION: THE LAST DEFENSIVE LINE AGAINST BILE ACID TOXICITY DURING CHOLESTASIS.

2025-08-28

Abstract excerpt

Glucuronidation is a detoxification reaction for bile acids (BA). The present study evaluates its efficiency to protect liver cells during acute (biliary obstruction, BO) and chronic (primary biliary cholangitis, PBC and primary sclerosing cholangitis, PSC) cholestatic situations. BA-glucuronides (G) were first profiled in sera from control, PBC, PSC and BO donors. An impressive accumulation of BA-Gs, formed from...

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Literature Corpus work: e8c934cb-cffa-5ebc-9cc7-792d9e9de401
DOI: 10.1101/2025.08.23.671933

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