Article

Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation

2024-09-26

Abstract excerpt

<title>Abstract</title> <p>Conjugated bile acids (BAs) are multi-functional detergents produced in the gastrointestinal (GI) tract by the liver enzyme bile acid:amino acid N-acyltransferase (BAAT) and by the microbiome from acyltransferase activity of the ubiquitous enzyme bile salt hydrolase (BSH). Humans with inflammatory bowel disease (IBD) have an enrichment in both host and microbially conjugated BAs (MCBAs)...

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Literature Corpus work: ca2c2b39-b573-5dbe-b37c-0e348e83f595
DOI: 10.21203/rs.3.rs-5005563/v1

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