Article
Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases.
Wiener medizinische Wochenschrift (1946) - 1 Jan 2008
Trauner Michael, Fickert Peter, Halilbasic Emina, Moustafa Tarek
Abstract excerpt
Alterations in bile secretion at the hepatocellular and cholangiocellular levels may cause cholestasis. Formation of 'toxic bile' may be the consequence of abnormal bile composition and can result in hepatocellular and/or bile duct injury. The canalicular phospholipid flippase (Mdr2/MDR3) normally mediates biliary excretion of phospholipids, which normally form mixed micelles with bile acids and cholesterol to...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- Animals
- Bile
- Bile Acids and Salts
- Bile Canaliculi
- Bile Duct Neoplasms
- Bile Ducts, Intrahepatic
- Carcinoma, Hepatocellular
- Cell Transformation, Neoplastic
- Cholangiocarcinoma
- Cholangitis, Sclerosing
- Cholestasis, Intrahepatic