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Differential role for hepatic glucuronidation and sulfonation in controlling the 24S- hydroxycholesterol ability activate LXR

2025-08-11

Abstract excerpt

<title>Abstract</title> <p> 24S-hydroxycholesterol (24SOH-Chol) is a bioactive cholesterol metabolite formed in the brain. This endogenous activator of the cholesterol sensor, liver X receptor (LXR) is abundantly found as a sulfate-glucuronide diconjugate in the human plasma. The present study characterizes the human sulfonating (SULT) and glucuronidating (UGT) enzymes; and evaluates how these enzymes impact its...

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Literature Corpus work
7f84280e-13a1-5894-9ed9-5822fe0a9068
DOI
10.21203/rs.3.rs-7142616/v1
Open publication

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Differential role for hepatic glucuronidation and sulfonation in controlling the 24S- hydroxycholesterol ability activate LXRDOI 10.21203/rs.3.rs-7142616/v1
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