Article
Bile acid receptors in the biliary tree: TGR5 in physiology and disease.
Biochimica et biophysica acta. Molecular basis of disease - 1 Apr 2018
Deutschmann Kathleen, Reich Maria, Klindt Caroline, Dröge Carola, Spomer Lina, Häussinger Dieter, Keitel Verena
Abstract excerpt
Bile salts represent signalling molecules with a variety of endocrine functions. Bile salt effects are mediated by different receptor molecules, comprising ligand-activated nuclear transcription factors as well as G protein-coupled membrane-bound receptors. The farnesoid X receptor (FXR) and the plasma membrane-bound G protein-coupled receptor TGR5 (Gpbar-1) are prototypic bile salt receptors of both classes and...
Topics
- Animals
- Bicarbonates
- Bile Acids and Salts
- Bile Ducts
- Cell Proliferation
- Cholangitis
- Cysts
- Disease Models, Animal
- Epithelial Cells
- Genetic Predisposition to Disease
- Humans