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Article

Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids.

Journal of hepatology - 1 Apr 2010

Erichsen Thomas J, Aehlen André, Ehmer Ursula, Kalthoff Sandra, Manns Michael P, Strassburg Christian P

Abstract excerpt

BACKGROUND & AIMS: Cholestasis is a serious complication of many liver diseases leading to increased serum bile acids (BA) and their conjugates. Chenodeoxycholic (CDCA) acid is a substrate of the human hepatic UDP-glucuronosyltransferase (UGT) 1A3. UGT1A3 may, therefore, be a BA-inducible gene relevant to BA regulation. METHODS: BA and human bile were used to induce UGT1A3 in HepG2 cells. Genomic DNA was analyzed...

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PMID: 20189675
DOI: 10.1016/j.jhep.2010.01.010

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