Article

Detection and characterization of Hepatitis B virus double-stranded linear DNA-derived covalently closed circular DNA in chronic hepatitis B patients

2025-01-23

Abstract excerpt

<h4>Background and Aims</h4> Hepatitis B virus (HBV) generates a double-stranded linear DNA (dslDNA) byproduct during replication. This dslDNA can undergo intermolecular and intramolecular nonhomologous end-joining (NHEJ) recombination, resulting in viral integration and dslDNA derived covalently closed circular DNAs (dsl-cccDNAs), respectively. The insertions and deletions (INDELs) at the end-joining site around...

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Literature Corpus work: e879e681-fa69-57ef-a228-ff7d1627e12d
DOI: 10.1101/2025.01.20.25320854

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