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New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation

6 Nov 2020

Abstract excerpt

The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a genuine cure for HBV. Yet how HBV cccDNA is formed from the viral genomic relaxed circular DNA...

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PMID: 33172220
DOI: 10.3390/cells9112430

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