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Clinical relevance of the study of hepatitis B virus covalently closed circular DNA

1 Jan 2016

Abstract excerpt

Hepatitis B virus (HBV) remains a public health concern with 240 million people affected worldwide. HBV is an hepadnavirus that replicates its genome in hepatocytes. One of the key steps of the viral life cycle is the formation of cccDNA - covalently closed circular DNA - in the nucleus, the equivalent of a viral mini-chromosome that acts as a template for subsequent virus replication. Current antiviral...

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PMID: 26725901
DOI: 10.1111/liv.13001

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