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A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation—and Beyond?

22 May 2017

Abstract excerpt

Chronic hepatitis B virus (HBV) infection puts more than 250 million people at a greatly increased risk to develop end-stage liver disease. Like all hepadnaviruses, HBV replicates via protein-primed reverse transcription of a pregenomic (pg) RNA, yielding an unusually structured, viral polymerase-linked relaxed-circular (RC) DNA as genome in infectious particles. Upon infection, RC-DNA is converted into nuclear...

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PMID: 28531167
DOI: 10.3390/v9050125

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