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Research progress in hepatitis B virus covalently closed circular DNA

22 Dec 2021

Abstract excerpt

Hepatitis B virus (HBV) infections are a global public health issue. HBV covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is a key factor in the HBV replication cycle. Notably, many host factors involved in HBV cccDNA epigenetic modulation promote the development of hepatocellular carcinoma (HCC). The HBV cccDNA minichromosome is a clinical obstacle that cannot be...

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PMID: 34931766
DOI: 10.20892/j.issn.2095-3941.2021.0454

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