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Article

Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA.

Emerging microbes & infections - 21 Jun 2017

Rybicka Magda, Woziwodzka Anna, Romanowski Tomasz, Stalke Piotr, Dręczewski Marcin, Bielawski Krzysztof Piotr

Abstract excerpt

The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue. The serum and liver biopsy samples were collected at the same time from 67 chronically infected patients. The genotyping of the RCDNA and cccDNA was performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28634352
DOI: 10.1038/emi.2017.41
PMCID: PMC5520316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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