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Article

Role of hepatitis B virus in development of hepatocellular carcinoma: Focus on covalently closed circular DNA

19 May 2022

Abstract excerpt

Chronic infection with hepatitis B virus (HBV) remains a major global health problem, especially in developing countries. It may lead to prolonged liver damage, fibrosis, cirrhosis, and hepatocellular carcinoma. Persistent chronic HBV infection is related to host immune response and the stability of the covalently closed circular DNA (cccDNA) in human hepatocytes. In addition to being essential for viral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35721287
DOI: 10.4254/wjh.v14.i5.866

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