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Approaches to quantifying hepatitis B virus covalently closed circular DNA

22 Oct 2021

Abstract excerpt

Chronic hepatitis B is a major cause of liver disease worldwide and is currently incurable. Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is a key form of the virus responsible for its persistence and is the transcriptional template for all viral transcripts. The field is focussed on methods to clear HBV cccDNA but this been limited by technical difficulties in its quantification due to: identical...

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PMID: 34674513
DOI: 10.3350/cmh.2021.0283

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