Article

Preferred endocytosis of amyloid precursor protein from cholesterol-enriched lipid raft microdomains

2020-06-26

Abstract excerpt

Amyloid precursor protein (APP) at the plasma membrane is internalized via endocytosis, and delivered to endosomes and lysosomes, where neurotoxic amyloid-β (Aβ) is produced via β-, γ-secretases. Hence, endocytosis plays a key role in the processing of APP and subsequent Aβ generation. β-, γ-secretases as well as APP are localized in cholesterol-enriched lipid raft microdomains. However, it is still unclear whethe...

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Literature Corpus work: e86b314d-0532-5d5d-bfa7-1e3433d53cae
DOI: 10.1101/2020.06.26.172874

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