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Article

Caveolin-1 regulates γ-secretase-mediated AβPP processing by modulating spatial distribution of γ-secretase in membrane.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Kapoor Arun, Hsu Wen-Ming, Wang Bo-Jeng, Wu Guan-Hsun, Lin Ti-Yu, Lee Shyh-Jye, Yen Chen-Tung, Liang Shu-Mei, Liao Yung-Feng

Abstract excerpt

Amyloidogenic processing of amyloid-β precursor protein (AβPP) is associated with cholesterol- and sphingolipid-rich lipid rafts. Caveolin-1, a raft-residing protein, has been implicated in the pathogenesis of Alzheimer's disease. To determine the role of caveolin-1 in governing γ-secretase-media...

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Source

Identifiers

PMID: 20847442
DOI: 10.3233/JAD-2010-100531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20847442-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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