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Article

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.

Brain research - 3 Nov 2009

Harris Benjamin, Pereira Isabel, Parkin Edward

Abstract excerpt

ADAM10 (a disintegrin and metalloproteinase 10) is the principal alpha-secretase responsible for the non-amyloidogenic processing of the Alzheimer's disease (AD)-associated amyloid precursor protein (APP). A reciprocal relationship exists between non-amyloidogenic and amyloidogenic APP processing such that impaired ADAM10-mediated proteolysis of the protein serves to enhance amyloidogenic processing (by beta- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19679113
DOI: 10.1016/j.brainres.2009.07.105

Genes

ADAM10
APP
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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