Article
Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2007
Yoon Il-Sang, Chen Eunice, Busse Tracy, Repetto Emanuela, Lakshmana Madepalli K, Koo Edward H, Kang David E
Abstract excerpt
The major defining pathological hallmark of Alzheimer's disease (AD) is the accumulation of amyloid beta protein (Abeta), a small peptide derived from beta- and gamma-secretase cleavages of the amyloid precursor protein (APP). Recent studies have shown that beta- and gamma-secretase activities of BACE1 and presenilin, respectively, are concentrated in intracellular lipid raft microdomains. However, the manner in...
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