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Article

Localization of mature neprilysin in lipid rafts.

Journal of neuroscience research - 1 Apr 2012

Sato Kimihiko, Tanabe Chiaki, Yonemura Yoji, Watahiki Haruhiko, Zhao Yimeng, Yagishita Sosuke, Ebina Maiko, Suo Satoshi, Futai Eugene, Murata Masayuki, Ishiura Shoichi

Abstract excerpt

Alzheimer's disease (AD) is characterized by senile plaques caused by amyloid-β peptide (Aβ) accumulation. It has been reported that Aβ generation and accumulation occur in membrane microdomains, called lipid rafts, which are enriched in cholesterol and glycosphingolipids. Moreover, the ablation of cholesterol metabolism has been implicated in AD. Neprilysin (NEP), a neutral endopeptidase, is one of the major...

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Identifiers

PMID: 22183801
DOI: 10.1002/jnr.22796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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