Article
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.
The Journal of biological chemistry - 22 Oct 2004
Vetrivel Kulandaivelu S, Cheng Haipeng, Lin William, Sakurai Takashi, Li Tong, Nukina Nobuyuki, Wong Philip C, Xu Huaxi, Thinakaran Gopal
Abstract excerpt
Alzheimer's disease-associated beta-amyloid peptides (Abeta) are generated by the sequential proteolytic processing of amyloid precursor protein (APP) by beta- and gamma-secretases. There is growing evidence that cholesterol- and sphingolipid-rich membrane microdomains are involved in regulating trafficking and processing of APP. BACE1, the major beta-secretase in neurons is a palmitoylated transmembrane protein...
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