Article
Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.
Molecular brain - 21 Apr 2010
Lorenzen Angela, Samosh Jonathan, Vandewark Kenneth, Anborgh Pieter H, Seah Claudia, Magalhaes Ana C, Cregan Sean P, Ferguson Stephen S G, Pasternak Stephen H
Abstract excerpt
BACKGROUND: A central feature of Alzheimer's disease is the cleavage of the amyloid precursor protein (APP) to form beta-amyloid peptide (Abeta) by the beta-secretase and gamma-secretase enzymes. Although this has been shown to occur after endocytosis of APP from the cell surface, the exact compartments of APP processing are not well defined. We have previously demonstrated that APP and gamma-secretase proteins...
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