Article

WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans

2023-04-22

Abstract excerpt

<h4>Background and aims</h4> WNT2B is a canonical Wnt ligand previously thought to be fully redundant with other Wnts in the intestinal epithelium. However, humans with WNT2B deficiency have severe intestinal disease, highlighting a critical role for WNT2B. We sought to understand how WNT2B contributes to intestinal homeostasis. <h4>Methods</h4> We investigated the intestinal health of Wnt2b knock out (KO) mice...

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Literature Corpus work: e86a9d1a-d52d-5dcc-9c5e-1b240eb8fcca
DOI: 10.1101/2023.04.21.537894

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