Article

Loss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid Handling

2026-01-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Ubiquitin-dependent signaling is essential for maintaining intestinal homeostasis and its dysregulation contributes to chronic intestinal disorders, such as Inflammatory Bowel Disease (IBD). Ube4A is a U-box E3/E4 ubiquitin ligase involved in lipid metabolism and insulin signaling in metabolic tissues. Autoantibodies against Ube4A have been identified in patients with IBD an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56e1a4e5-42fd-5f2f-952c-2f5326c896a4
DOI: 10.64898/2026.01.02.697430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid HandlingDOI 10.64898/2026.01.02.697430Read

The Role of E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe?Semantic proximity Read

Epithelial CRL4 DCAF2 is critical for maintaining intestinal homeostasis by regulating the proliferation and repair of intestinal epithelial cellsSemantic proximity Read

Coronin1A regulates tumor microenvironment in colitis-associated colorectal cancer in a SUMO-dependent waySemantic proximity Read

Transcriptome profiling of ulcerative colitis mouse model suggests biomarkers and therapeutic targets for human colitisSemantic proximity Read

Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitisSemantic proximity Read

RNF43 is a gatekeeper for colitis-associated cancerSemantic proximity Read

WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in HumansSemantic proximity Read

Combined suppression of HNF4α and HNF4γ Drives a Reversible Epithelial-Intrinsic Barrier Defect in Crohn’s DiseaseSemantic proximity Read

IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseasesSemantic proximity Read

Smad4 Loss in the Mouse Intestinal Epithelium Alleviates the Pathological Fibrotic Response to Injury in the ColonSemantic proximity Read

IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseasesSemantic proximity Read

Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.Semantic proximity Read