Article

Gut Microbial Impact on Colitis and Colitis-Associated Carcinogenesis in a Primary Sclerosing Cholangitis-IBD Model

2024-10-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Primary sclerosing cholangitis (PSC) associated inflammatory bowel diseases (IBD) increase colorectal dysplasia and malignancy risk. Current mouse models do not adequately replicate human PSC-IBD, limiting mechanistic understanding and therapeutic development. This study uses Mdr2/Il10 double knockout (DKO) mice to examine microbiota roles in mediating colitis, col...

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Literature Corpus work: 9767f680-b052-5a8c-affa-95705f1c6225
DOI: 10.1101/2024.10.03.616279

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