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Mesenchymal WNT2B is required for the development and function of the human intestine

2025-05-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> WNT2B mutations result in Diarrhea-9 (DIAR9), a congenital diarrhea syndrome with an extreme phenotype and unique histological defects. Attempts to model DIAR9 in rodents and study patient epithelial tissue have not been able to fully reproduce the human phenotype, making understanding this condition challenging. Here, we aimed to interrogate the mechanisms and the...

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Literature Corpus work
da1cd1ae-f9fd-5bb8-bd01-4f6957438406
DOI
10.1101/2025.05.01.651727
Open publication

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Mesenchymal WNT2B is required for the development and function of the human intestineDOI 10.1101/2025.05.01.651727
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