Article

Resolving Local and Global Conformational Heterogeneity of the Human Intrinsically Disordered Proteome

2025-12-18

Abstract excerpt

Linking the sequences of intrinsically disordered regions (IDRs) to their structural ensembles and biological functions remains a central challenge in understanding how disorder encodes activity. A recent study has shown that human IDRs with different levels of compactness, as measured by Flory’s exponent, are associated with specific cellular functions and localizations, and Flory’s exponent can be predicted from...

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Literature Corpus work: e86a7e68-692a-58b8-a4ed-b29f6dc5732b
DOI: 10.64898/2025.12.16.694679

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