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Mycobacterium tuberculosis uses intrinsically disordered, fast evolving proteins to interact with conserved host factors

23 Nov 2025

Abstract excerpt

BACKGROUND: Intrinsically disordered protein regions (IDRs) are implicated in diverse cellular processes in eukaryotes and, in these organisms, they cover up to 40% of the proteome. Surprisingly little is known about IDRs in bacterial proteomes. Specifically, a number of questions remain unanswered, such as the role of these regions in host-pathogen interactions, their adaptive potential and evolutionary...

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PMID: 41276815
DOI: 10.1186/s13059-025-03854-6

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