Article

Sequence-encoded conformational biases shape self-assembly modes of intrinsically disordered proteins

2025-10-27

Abstract excerpt

Self-assembly of intrinsically disordered proteins (IDPs) underlies cellular functions and disease pathogenesis. This process is mediated by two intermolecular interaction modes: transient point-to-point contacts described by the sticker-and-spacer framework, and persistent surface-to-surface contacts proposed in the cross-β hypothesis. We investigated the molecular basis of these modes in the context of conformat...

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Literature Corpus work: 96abf913-3249-5d41-ba89-8ffd2dbb4364
DOI: 10.1101/2025.10.27.683987

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