Article

Interpretable Prediction of Phase Separation and Disease Variant Effects in Intrinsically Disordered Regions

2026-07-20

Abstract excerpt

Coding mutations within intrinsically disordered regions (IDRs) of proteins are increasingly implicated in human diseases yet remain poorly interpreted by conventional variant-effect predictors that rely on structural stability and conservation-based metrics. Quantifying disruption of IDR-mediated liquid-liquid phase separation (LLPS) offers a biophysically principled approach to interpreting the pathogenic impact...

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Literature Corpus work: b37f2783-184d-5596-9d5a-8c0012239401
DOI: 10.64898/2026.07.14.736885

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