Article

Decoding conformational heterogeneity across disordered proteomes

2026-03-16

Abstract excerpt

Intrinsically disordered proteins (IDPs) comprise nearly one-third of the human proteome and play key roles in regulation, signaling, and disease, yet their dynamic nature has resisted accurate structural prediction even by the state of the art deep-learning methods. Here we introduce AI-IDP, a framework combining established deep-learning structure prediction of isolated short IDP fragments with their flexible ph...

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Literature Corpus work: 93b3ce5c-3015-5e55-9993-0b0e0b979036
DOI: 10.64898/2026.03.13.711260

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