Article

A Functional Map of the Human Intrinsically Disordered Proteome

2024-03-17

Abstract excerpt

Intrinsically disordered regions (IDRs) represent at least one-third of the human proteome and defy the established structure-function paradigm. Because IDRs often have limited positional sequence conservation, the functional classification of IDRs using standard bioinformatics is generally not possible. Here, we show that evolutionarily conserved molecular features of the intrinsically disordered human proteome (...

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Literature Corpus work: 9d68c35d-21c8-5f64-ad7f-4482911cf557
DOI: 10.1101/2024.03.15.585291

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