Article

Therapy-induced senescence upregulates antigen presentation machinery and triggers anti-tumor immunity in Acute Myeloid Leukemia

2022-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Acute myeloid leukemia (AML) is an aggressive hematological malignancy often curable only by using intensive chemotherapy. Nonetheless, resistance/early relapses are frequent, underscoring the need to investigate the molecular events occurring shortly after chemotherapy. Therapy-induced senescence (TIS) is a fail-safe tumor suppressive mechanism that may elicit immune-mediated responses contribu...

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Literature Corpus work: e86319f3-2384-545a-85ce-a84243a4ca00
DOI: 10.1101/2022.11.17.515658

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