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Article

Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence.

Cancer discovery - 1 Jun 2021

Duy Cihangir, Li Meng, Teater Matt, Meydan Cem, Garrett-Bakelman Francine E, Lee Tak C, Chin Christopher R, Durmaz Ceyda, Kawabata Kimihito C, Dhimolea Eugen, Mitsiades Constantine S, Doehner Hartmut, D'Andrea Richard J, Becker Michael W, Paietta Elisabeth M, Mason Christopher E, Carroll Martin, Melnick Ari M

Abstract excerpt

Patients with acute myeloid leukemia (AML) frequently relapse after chemotherapy, yet the mechanism by which AML reemerges is not fully understood. Herein, we show that primary AML cells enter a senescence-like phenotype following chemotherapy in vitro and in vivo. This is accompanied by induction of senescence/inflammatory and embryonic diapause transcriptional programs, with downregulation of MYC and leukemia...

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Share to Cell Line, Tumor
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

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Identifiers

PMID: 33500244
DOI: 10.1158/2159-8290.CD-20-1375
PMCID: PMC8178167

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