Article

Signatures of immune senescence predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia

2022-02-09

Abstract excerpt

<h4>Summary</h4> The function of senescent-like T cells, transcriptomic features of immune effector senescence (IES) and their influence on therapeutic response were investigated in independent AML clinical cohorts comprising 1,864 patients treated with chemotherapy and/or immune checkpoint blockade (ICB). We show that senescent-like bone marrow CD8 + T cells are impaired in killing autologous AML blasts, and that...

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Literature Corpus work: aa9c2f6d-e0f5-5c7e-9c58-113a83bebe91
DOI: 10.1101/2022.02.08.22270578

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