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Therapy-Induced Senescence: Novel Approaches for Markers Identification

2 Aug 2024

Abstract excerpt

Therapy-induced senescence (TIS) represents a major cellular response to anticancer treatments. Both malignant and non-malignant cells in the tumor microenvironment undergo TIS and may be harmful for cancer patients since TIS cells develop a senescence-associated secretory phenotype (SASP) that can sustain tumor growth. The SASP also modulates anti-tumor immunity, although the immune populations involved and the...

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PMID: 39126015
DOI: 10.3390/ijms25158448

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