Article

Induction of senescence renders cancer cells highly immunogenic

2022-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a stress response that activates innate immunity. However, the interplay between senescent cells and the adaptive immune system remains largely unexplored. Here, we show that senescent cells display enhanced MHC class I (MHC-I) antigen processing and presentation. Immunization of mice with senescent syngeneic fibroblasts generates CD8 T cells reactive against both normal a...

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Literature Corpus work: 7a740f28-ec6d-5f9e-a2cb-fdc0d49fee48
DOI: 10.1101/2022.06.05.494912

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