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Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy

1 Nov 2018

Abstract excerpt

BACKGROUND: Our understanding of phenotypic and functional signatures of CD8+ T cell dysfunction in acute myeloid leukemia (AML) is limited. Deciphering these deranged T cell functional states and how they are impacted by induction chemotherapy is essential for incorporation of novel immune-based strategies to restore and maintain antileukemia immunity. METHODS: We utilized high-dimensional immunophenotyping,...

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PMID: 30385732
DOI: 10.1172/jci.insight.120974

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