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Article

Optimal combination of immune checkpoint and senescence molecule predicts adverse outcomes in patients with acute myeloid leukemia.

Annals of medicine - 1 Dec 2023

Wang Peipei, Zhang Yuling, Cai Qinghua, Long Qingqin, Pan Shiyi, Zhou Wei, Deng Tingfen, Mo Wenjian, Wang Shunqing, Zhang Yuping, Wang Caixia, Chen Cunte

Abstract excerpt

BACKGROUND: High expression of immune checkpoints (ICs) and senescence molecules (SMs) contributes to T cell dysfunction, tumor escape, and progression, but systematic evaluation of them in co-expression patterns and prognosis in acute myeloid leukemia (AML) was lacking. METHODS: Three publicly available datasets (TCGA, Beat-AML, and GSE71014) were first used to explore the effect of IC and SM combinations on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37070487
DOI: 10.1080/07853890.2023.2201507
PMCID: PMC10120552

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