Article

ERK overstimulation leads to cell hyperproliferation in hereditary hemorrhagic telangiectasia landscape

2026-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular disorder caused by pathogenic variants in members of the BMP9/ALK1 signaling hub. In the present study we show that, regardless of whether the alterations are caused by reduced BMP9/ALK1 signaling (pathogenic variants in the ENG or ALK1 genes) or by overactivation of this pathway (such as the SMAD6 pathogenic variants), all are as...

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Literature Corpus work: 20eedb11-b1d0-53ef-b4d3-d4e55ac4d5e3
DOI: 10.64898/2026.07.07.737030

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