Article

Controlled Induction of ALK1 in <i>ACVRL1</i> -null hiPSC-derived Endothelial Cells Provides Insight into Organ-Restricted AVMs in HHT

2025-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Genetic alterations in activin receptor-like kinase 1 ( ACVRL1 , ALK1) are linked to hereditary hemorrhagic telangiectasia (HHT), a condition characterized by hemorrhages, arteriovenous malformations (AVMs) and endothelial cell (EC) dysfunction. Haploinsufficiency is considered the central disease-driving mechanism, but it remains unclear why vascular lesions are tissue-restricted. To investiga...

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Literature Corpus work: 9fe438ce-a6fd-5ce3-add9-5fe1073a4e98
DOI: 10.1101/2025.08.22.671484

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