R-Loops at Chromosome Ends: From Formation, Regulation, and Cellular Consequence

doi:10.3390/cancers15072178

Article

R-Loops at Chromosome Ends: From Formation, Regulation, and Cellular Consequence

6 Apr 2023

Abstract excerpt

Telomeric repeat containing RNA (TERRA) is transcribed from subtelomeric regions to telomeres. TERRA RNA can invade telomeric dsDNA and form telomeric R-loop structures. A growing body of evidence suggests that TERRA-mediated R-loops are critical players in telomere length homeostasis. Here, we will review current knowledge on the regulation of R-loop levels at telomeres. In particular, we will discuss how the...

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