Article

Meso-limbic Gene Expression Findings from Mouse Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder

2020-02-02

Abstract excerpt

Animal models of drug use have been employed for over 100 years to facilitate the identification of mechanisms governing human substance use and addiction. Most cross-species research on drug use/addiction examines behavioral overlap, but studies assessing neuro-molecular correspondence are lacking. Our study utilized transcriptome-wide data from the hippocampus and ventral tegmental area (VTA)/midbrain from a tot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2855c4a9-8620-5a19-a62b-176dd1c28506
DOI: 10.1101/2020.01.31.929406

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Meso-limbic Gene Expression Findings from Mouse Cocaine Self-Administration Recapitulate Human Cocaine Use DisorderDOI 10.1101/2020.01.31.929406Read

Consideration of genetic and sex effects in mice enhances consilience with human addiction studiesSemantic proximity Read

Sex-specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent BrainsSemantic proximity Read

Transcriptional signatures of heroin intake and seeking throughout the brain reward circuitSemantic proximity Read

Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusersSemantic proximity Read

Conserved Cell-Type-Specific Transcriptomic Networks and Regulatory Programs Underlie Alcohol Dependence Across Mouse and HumanSemantic proximity Read

Molecular genetics of cocaine use disorders in humansSemantic proximity Read

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.Semantic proximity Read

Identification of miRNA-mediated gene regulatory networks in L-methionine exposure counteracts cocaine-conditioned place preference in miceSemantic proximity Read

Dynamic alterations in gene co-expression networks and gene-transcript associations characterize co-morbidities in cocaine use disorderSemantic proximity Read

Transcriptomic signatures of sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypesSemantic proximity Read

Bulk and Single-cell Transcriptomic Brain Data Identify Overlapping Processes and Cell-types with Human AUD and Mammalian Models of Alcohol UseSemantic proximity Read

Advancing substance use disorder biology by studying underlying gene x environment interactions.Semantic proximity Read