Article

Thousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals

2022-05-03

Abstract excerpt

The synthesis of most proteins begins at AUG codons, yet a small number of non-AUG initiated proteoforms are also known. Here we used publicly available ribo-seq data with phylogenetic approaches to identify novel, previously uncharacterised non-AUG proteoforms. Unexpectedly we found that the number of non-AUG proteoforms identified with ribosome profiling data greatly exceeds those with strong phylogenetic suppor...

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Literature Corpus work: e7eb5b68-ea06-562b-8635-60ccbf7ef173
DOI: 10.1101/2022.05.02.490320

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