Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Illuminating mitochondrial translation through mouse models.

Human molecular genetics - 22 May 2024

Hughes Laetitia A, Rackham Oliver, Filipovska Aleksandra

Abstract excerpt

Mitochondria are hubs of metabolic activity with a major role in ATP conversion by oxidative phosphorylation (OXPHOS). The mammalian mitochondrial genome encodes 11 mRNAs encoding 13 OXPHOS proteins along with 2 rRNAs and 22 tRNAs, that facilitate their translation on mitoribosomes. Maintaining the internal production of core OXPHOS subunits requires modulation of the mitochondrial capacity to match the cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Genome, Mitochondrial
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Diseases

Share to Mitochondrial Proteins

Share to Oxidative Phosphorylation

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 38779771
DOI: 10.1093/hmg/ddae020
PMCID: PMC11112386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Illuminating mitochondrial translation through mouse models.PMID 38779771Read ↗

The Diseased Mitoribosome.Semantic proximity Read ↗

Mitochondrial DNA transcription and translation: clinical syndromes.Semantic proximity Read ↗

Molecular Insights into Mitochondrial Protein Translocation and Human Disease.Semantic proximity Read ↗

DELE1 maintains muscle proteostasis to promote growth and survival in mitochondrial myopathySemantic proximity Read ↗

Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation.Semantic proximity Read ↗

Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and diseaseSemantic proximity Read ↗

Blackout in the powerhouse: clinical phenotypes associated with defects in the assembly of OXPHOS complexes and the mitoribosome.Semantic proximity Read ↗

Human Mitoribosome Biogenesis and Its Emerging Links to Disease.Semantic proximity Read ↗

Translation of MT-ATP6 pathogenic variants reveals distinct regulatory consequences from the co-translational quality control of mitochondrial protein synthesis.Semantic proximity Read ↗

mRNA Trafficking and Local Translation: Shaping Mitochondria in the SynapseSemantic proximity Read ↗

Disease models of mitochondrial aminoacyl-tRNA synthetase defects.Semantic proximity Read ↗

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.