Article
5' UTR length shapes alternative N-terminal protein isoforms across cancers and in rare disease.
EMBO reports - 1 May 2026
Ly Jimmy, Smith Eric M, Di Bernardo Matteo, Tao Yi Fei, Black Elizabeth M, Khalizeva Ekaterina, Cheeseman Iain M
Abstract excerpt
The 5' untranslated region (5' UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5' UTR length plays a direct role in alternative N-terminal protein isoform production by controlling start codon selection. We find that very short 5' UTRs enhance leaky ribosome scanning, thereby promoting...
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