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Article

Alternative translation initiation augments the human mitochondrial proteome.

Nucleic acids research - 1 Feb 2013

Kazak Lawrence, Reyes Aurelio, Duncan Anna L, Rorbach Joanna, Wood Stuart R, Brea-Calvo Gloria, Gammage Payam A, Robinson Alan J, Minczuk Michal, Holt Ian J

Abstract excerpt

Alternative translation initiation (ATI) is a mechanism of producing multiple proteins from a single transcript, which in some cases regulates trafficking of proteins to different cellular compartments, including mitochondria. Application of a genome-wide computational screen predicts a cryptic mitochondrial targeting signal for 126 proteins in mouse and man that is revealed when an AUG codon located downstream...

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Source

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Identifiers

PMID: 23275553
DOI: 10.1093/nar/gks1347
PMCID: PMC3575844

Genes

PABPC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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