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Article

HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.

The Journal of membrane biology - 1 Dec 2015

Magee Kaylee E A, Madden Zarina, Young Edgar C

Abstract excerpt

Hyperpolarization- and cyclic nucleotide-activated (HCN) channels contribute to rhythmic oscillations in excitable cells. They possess an intrinsic autoinhibition with a hyperpolarized V 1/2, which can be relieved by cAMP binding to the cyclic nucleotide binding (CNB) fold in the C-terminal region or by deletion of the CNB fold. We questioned whether V 1/2 shifts caused by altering the autoinhibitory CNB fold...

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Source

Identifiers

PMID: 26123597
DOI: 10.1007/s00232-015-9816-7

Genes

HCN2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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