Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family.

doi:10.1085/jgp.201812031

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Article

Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family.

The Journal of general physiology - 6 Aug 2018

Alvarez-Baron Claudia P, Klenchin Vadim A, Chanda Baron

Abstract excerpt

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate rhythmic activity in the heart and brain. Isoform-specific functional differences reflect the specializations required for the various roles that they play. Despite a high sequence and structural similarity, HCN isoforms differ greatly in their response to cyclic nucleotides. Cyclic AMP (cAMP) enhances the activity of HCN2 and HCN4...

Topics

Animals
Cyclic AMP
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Mice
Models, Chemical
Mutation
Oocytes
Protein Isoforms
Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 29980633
DOI: 10.1085/jgp.201812031
PMCID: PMC6080897

Genes

HCN2
HCN1
HCN3
HCN4

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